TDA is a broad-spectrum antimicrobial compound produced by several members of the Rhodobacteraceae family, a major marine bacterial lineage, within the genera Phaeobacter, Tritonibacter and Pseudovibrio. An example of a versatile bacterial secondary metabolite with multiple functions is the tropone derivative tropodithietic acid (TDA). However, several of these metabolites also possess non-antimicrobial functions, both influencing the physiology of the producer and their ecological neighbors. N2 - Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. T1 - Role is in the eye of the beholder - the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae Here, we summarize the current understanding of the chemical ecology of TDA, including the environmental niches of TDA-producing bacteria, and the molecular mechanisms governing the function and regulation of TDA.", In microbial communities, TDA-producing bacteria cause a reduction of the relative abundance of closely related species and some fast-growing heterotrophic bacteria. TDA also acts as a signaling molecule, affecting gene expression in other bacteria, and altering phenotypic traits such as motility, biofilm formation, and antibiotic production in the producer. The antibacterial effect of TDA is caused by disruption of the proton motive force of target microorganisms and, potentially, by its iron-chelating properties. The production of TDA is governed by the mode of growth and influenced by the availability of nutrient sources. Here, we summarize the current understanding of the chemical ecology of TDA, including the environmental niches of TDA-producing bacteria, and the molecular mechanisms governing the function and regulation of TDA.Ībstract = "Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. Bringing the immersion, wonder and epicness of a D&D campaign to the PC, the Eye of the Beholder is a genre-defining and beloved series for RPG and Dungeons & Dragons fans alike.Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. With an original story set in the Forgotten Realms universe, the Eye of the Beholder trilogy is based on the Advanced Dungeon & Dragons 2nd Edition’s game rules. The Forgotten Realms Archive – Collection One allows you to journey through one such set of adventures: the Eye of the Beholder trilogy, a set of first-person, real-time role-playing games. The Forgotten Realms world of Dungeons & Dragons has been home to many a hero and imagination since its publication, producing adventures and stories to be retold and enjoyed for years to come.
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